Dyslipidemia and thrombosis: causal relationship or epiphenomenon of sedentary lifestyle?
نویسندگان
چکیده
Relationship or Epiphenomenon of Sedentary Lifestyle? To the Editor: Doggen et al report that low HDL cholesterol and high triglyceride levels are associated with an increased risk for venous thrombosis in a population-based case–control study. The authors explain their results with an interaction of triglycerides with different coagulant factors as activated protein C (APC), factor VIIc, factor VIII, factor IX, and fibrinogen.1 However, low HDL cholesterol and high triglycerides are found frequently in subjects with a predominantly sedentary lifestyle and are key features of the metabolic syndrome.2 Individuals with the metabolic syndrome are characterized by prothrombotic hemostatic abnormalities such as elevated plasma fibrinogen, elevated factor VIIc, and raised concentrations of plasminogen activator inhibitor (PAI).3 Regular aerobic exercise leads to an improved metabolism of serum lipids with increased levels of HDL cholesterol and decreased plasma triglycerides, resulting in a lower risk of atherothrombotic events.4 Moreover, a recent publication shows that moderate-intensity aerobic exercise leads to a decreased platelet coagulation, hematocrit and blood viscosity, and PAI 1 antigen.5 All these factors are beneficial to hemostatic balance and presumably reduce the risk for thromboembolic events. However, Doggen et al provide no data on physical activity and basic hematologic parameters such as hematocrit. We suggest that the reported association of low HDL cholesterol and hypertriglyceridemia with thrombosis might be explained, besides the pathomechanisms discussed by Doggen et al,1 in part by lower physical activity resulting in a procoagulant state with increased coagulant factors and higher blood viscosity.
منابع مشابه
Gallstone Disease and Increased Risk of Ischemic Heart Disease: Causal Association or Epiphenomenon?
متن کامل
the causal relationship between school atmosphere and health-centered academic lifestyle behaviors mediating academic conflict in students
The aim of the present study was to investigate the causal relationship between school climate and health-oriented academic lifestyle behaviors mediating academic engagement in students. The statistical population included all elementary students (second year) of Boroujerd city in the academic year 2020-21 in the number of 16,000, of which 450 people were randomly selected as a sample. Research...
متن کاملImportance of recognizing occult renal disease in hypertensive patients.
INTRODUCTION AND OBJECTIVES Occult renal disease (ORD) is a condition that characterizes the early stages of renal failure and which cannot be detected by routine monitoring. The aims of this study were to determine the prevalence of ORD in hypertensive patients attending cardiology outpatient clinics and to identify its relationship with specific cardiovascular risk factors or treatment. MET...
متن کاملPersistent organochlorines, sedentary occupation, obesity and human male subfertility.
BACKGROUND Studies have suggested that the quality of human semen has been declining over recent decades, presumably because of lifestyle or environmental factors. METHODS Polychlorinated biphenyls and organochlorine pesticides were analysed in the plasma of 25 men with poor semen quality, 20 men with normal semen quality and idiopathic subfertility and 27 men with normal semen quality and fe...
متن کاملComparison of the effect of 8 weeks of aerobic and resistance training on lipid profile and blood pressure of inactive obese women with hypertension
Background and Objectives: Lack of physical activity is a worrying condition because it leads to major health problems such as obesity, high blood pressure and various metabolic disorders. Exercise is a lifestyle change suggested to reduce atherogenic markers in adults. Increased physical activity and fitness are clearly associated with a reduced risk of cardiovascular disease, but the optimal ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Arteriosclerosis, thrombosis, and vascular biology
دوره 25 3 شماره
صفحات -
تاریخ انتشار 2005